Capsule Resveratrolo: perché sono considerate un innovativo scudo cellulare

Pubblicazioni scientifiche

Alessio N, Squillaro T, Lettiero I, Galano G,
De Rosa R, Peluso G, Galderisi U, Di Bernardo G. Biomolecular Evaluation of
Piceatannol's Effects in Counteracting the Senescence of Mesenchymal Stromal
Cells: A New Candidate for Senotherapeutics? Int J Mol Sci. 2021 Oct
27;22(21):11619. doi: 10.3390/ijms222111619. PMID: 34769049; PMCID: PMC8583715.

Siraj Y, Aprile D, Alessio N, Peluso G, Di Bernardo G, Galderisi U.
IGFBP7 is a key component of the senescence-associated secretory phenotype
(SASP) that induces senescence in healthy cells by modulating the insulin, IGF,
and activin A pathways. Cell Commun Signal. 2024 Nov
12;22(1):540. doi: 10.1186/s12964-024-01921-2. PMID: 39533382; PMCID:
PMC11558980

Mazzone V, Alessio N, Aprile D, Galano G, De Rosa R, Schiraldi C, Di
Bernardo G, Galderisi U. Terpenes: natural compounds found in plants as
potential senotherapeutics targeting senescent mesenchymal stromal cells and
promoting apoptosis. Stem Cell Res Ther. 2025 May 9;16(1):231. doi:
10.1186/s13287-025-04310-9. PMID: 40346705; PMCID: PMC12065172.

Alessio N, Acar MB, Squillaro T, Aprile D, Ayaz-Güner Ş, Di Bernardo G,
Peluso G, Özcan S, Galderisi U. Progression of irradiated mesenchymal stromal
cells from early to late senescence: Changes in SASP composition and
anti-tumour properties. Cell Prolif. 2023
Jun;56(6):e13401. doi: 10.1111/cpr.13401. Epub 2023 Mar 22. PMID: 36949664;
PMCID: PMC10280137.

Oguma Y, Alessio N, Aprile D, Dezawa M, Peluso G, Di Bernardo G,
Galderisi U. Meta-analysis of senescent cell secretomes to identify common and
specific features of the different senescent phenotypes: a tool for developing
new senotherapeutics. Cell Commun Signal. 2023 Sep 28;21(1):262.
doi: 10.1186/s12964-023-01280-4. PMID: 37770897; PMCID: PMC10537976.

Alessio N, Ambrosino A, Boggi A, Aprile D, Pinto I, Galano G, Galderisi
U, Di Bernardo G. Germicidal lamps using UV-C radiation may pose health safety
issues: a biomolecular analysis of their effects on apoptosis and senescence.
Aging (Albany NY). 2024 May 2;16(9):7511-7522. doi: 10.18632/aging.205787. Epub
2024 May 2. PMID: 38700499; PMCID: PMC11131978.

Alessio N, Aprile D, Peluso G, Mazzone V, Patrone D, Di Bernardo G, Galderisi
U. IGFBP5 is released by senescent cells and is internalized by healthy cells,
promoting their senescence through interaction with retinoic receptors. Cell Commun Signal. 2024 Feb 13;22(1):122. doi:
10.1186/s12964-024-01469-1. PMID: 38351010; PMCID: PMC10863175.

Alessio N, Aprile D, Squillaro T, Di Bernardo G, Finicelli M, Melone MA,
Peluso G, Galderisi U. The senescence-associated secretory phenotype (SASP)
from mesenchymal stromal cells impairs growth of immortalized prostate cells
but has no effect on metastatic prostatic cancer cells. Aging (Albany NY). 2019
Aug 14;11(15):5817-5828. doi: 10.18632/aging.102172. Epub 2019 Aug 14. PMID:
31412320; PMCID: PMC6710033.

Özcan S, Alessio N, Acar MB, Toprak G, Gönen ZB, Peluso G, Galderisi U.
Myeloma cells can corrupt senescent mesenchymal stromal cells and impair their
anti-tumor activity. Oncotarget. 2015 Nov
24;6(37):39482-92. doi: 10.18632/oncotarget.5430. PMID: 26498687; PMCID:
PMC4741840.

Auti A, Alessio N, Ballini A, Dioguardi M, Cantore S, Scacco S, Vitiello
A, Quagliuolo L, Rinaldi B, Santacroce L, Di Domenico M, Boccellino M.
Protective Effect of Resveratrol against Hypoxia-Induced Neural Oxidative
Stress. J Pers Med. 2022 Jul 23;12(8):1202. doi:
10.3390/jpm12081202. PMID: 35893296; PMCID: PMC9330416.

Alessio N, Squillaro T, Di Bernardo G, Galano G, De Rosa R, Melone MAB,
Peluso G, Galderisi U. Increase of circulating IGFBP-4 following genotoxic
stress and its implication for senescence. Elife. 2020 Mar 30;9:e54523. doi:
10.7554/eLife.54523. Erratum in: Elife. 2022 Jul 01;11:e80871. doi:
10.7554/eLife.80871. PMID: 32223893; PMCID: PMC7136022.

Alessio N, Del Gaudio S, Capasso S, Di Bernardo G, Cappabianca S,
Cipollaro M, Peluso G, Galderisi U. Low dose radiation induced senescence of
human mesenchymal stromal cells and impaired the autophagy process. Oncotarget. 2015 Apr 10;6(10):8155-66. doi: 10.18632/oncotarget.2692.
PMID: 25544750; PMCID: PMC4480742.